Ethanol → 5-Methoxy-1-methyl-1H-pyrazole-4-carboxylic acid
반응식
[CH3:1][N:2]1[C:6]([O:7][CH3:8])=[C:5]([C:9]([O:11]CC)=[O:10])[CH:4]=[N:3]1.C(O)C.[OH-].[K+]>O>[CH3:1][N:2]1[C:6]([O:7][CH3:8])=[C:5]([C:9]([OH:11])=[O:10])[CH:4]=[N:3]1참가 물질
5
실험 절차
Ethyl 1-methyl-5-methoxypyrazole-4-carboxylate (1.4 g) was stirred at room temperature for 2 hours together with 30 ml of ethanol, 10 ml of water and 2 g of potassium hydroxide. Ethanol was removed from the reaction solution under reduced pressure. From the aqueous layer, 1.29 g (yield 99%) of the desired 1-methyl-5-methoxypyrazole-4-carboxylic acid was obtained by acid precipitation.
후처리
- customEthanol was removed from the reaction solution under reduced pressure
출처 및 근거
- ORD 기록
- ord-9e17d5a606c4429f92471d4c1dfad08e
- 출처 데이터셋
- uspto-grants-1988_12
- 특허 번호
- US04792565
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