Acetic Acid → 4-Methyl-6-acetamido-7-hydroxy-1-indanone

HRID 414678

반응식

HRID 414678 반응식
[CH3:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([OH:14])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:15].[C:16](O)(=[O:18])[CH3:17]>[C].[Pd]>[CH3:1][C:2]1[CH:10]=[C:9]([NH:11][C:16](=[O:18])[CH3:17])[C:8]([OH:14])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:15]

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 136041424-Methyl-6-nitro-7-hydroxy-1-indanone

생성물 1

HCID 136041464-Methyl-6-acetamido-7-hydroxy-1-indanone

시약·촉매·용매 1

HCID 178418390HCID 178418390, 화합물촉매

실험 절차

Into a solution of 11.5 g of 4-methyl-6-nitro-7-hydroxy-1-indanone in 500 ml of acetic acid was added 1.5 g of 5% palladium carbon, then the mixture was subjected to a catalytic hydrogenation under an atmospheric pressure at a room temperature. The catalyst was removed by filtration and the solvent was removed by evaporation. The residue obtained was washed with ether and was recrystallized from methanol to obtain 6.34 g of 4-methyl-6-acetamido-7-hydroxy-1-indanone.

후처리

  1. customwas subjected to a catalytic hydrogenation under an atmospheric pressure at a room temperature
  2. customThe catalyst was removed by filtration
  3. customthe solvent was removed by evaporation
  4. customThe residue obtained
  5. washwas washed with ether
  6. customwas recrystallized from methanol

출처 및 근거

ORD 기록
ord-acbcc05080a54311b75436cdf25ec350
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04792628

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