Allyl bromide → 4-Methyl-7-allyloxy-1-indanone

HRID 414679

반응식

HRID 414679 반응식
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12].[OH-].[K+].[CH2:15](Br)[CH:16]=[CH2:17]>CO>[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH2:17][CH:16]=[CH2:15])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 14797Potassium HydroxideHCID 124362447-Hydroxy-4-methyl-1-indanone

생성물 1

HCID 136041474-Methyl-7-allyloxy-1-indanone

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Into a solution of 36 g of 4-methyl-7-hydroxy-1-indanone and 17.6 g of potassium hydroxide in 650 ml of methanol was added 25 ml of allyl bromide, and the mixture was refluxed by heating for 6 hours. The insoluble matters in the reaction mixture were removed by filtration, then the solvent was removed by evaporation. The residue obtained was extracted with chloroform-water, and the chloroform layer was collected by separation, then the solvent was removed by evaporation. The residue thus obtained was washed with ether and purified by means of a column chromatography to obtain 32 g of 4-methyl-7-allyloxy-1-indanone.

후처리

  1. temperaturethe mixture was refluxed
  2. temperatureby heating for 6 hours
  3. customThe insoluble matters in the reaction mixture were removed by filtration
  4. customthe solvent was removed by evaporation
  5. customThe residue obtained
  6. extractionwas extracted with chloroform-water
  7. customthe chloroform layer was collected by separation
  8. customthe solvent was removed by evaporation
  9. customThe residue thus obtained
  10. washwas washed with ether
  11. custompurified by means of a column chromatography

출처 및 근거

ORD 기록
ord-2371e098b30d4753b8b9758abde13125
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04792628

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