MAGNESIUM SILICATE (synthetic) → Betulone Aldehyde

HRID 414903노트

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HRID 414903 반응식
[O-][Si]([O-])=O.[Mg+2].C([O-])(=O)C.[Na+].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[CH3:22][C:23]([C@H:25]1[C@@H:29]2[C@@H:30]3[C@@:43]([CH3:46])([CH2:44][CH2:45][C@@:28]2([CH2:52][OH:53])[CH2:27][CH2:26]1)[C@@:42]1([CH3:47])[C@@H:33]([C@:34]2([CH3:51])[C@@H:39]([CH2:40][CH2:41]1)[C:38]([CH3:49])([CH3:48])[C@@H:37]([OH:50])[CH2:36][CH2:35]2)[CH2:32][CH2:31]3)=[CH2:24]>C(Cl)Cl>[CH3:24][C:23]([C@H:25]1[C@@H:29]2[C@H:30]3[C@@:43]([CH3:46])([CH2:44][CH2:45][C@@:28]2([CH:52]=[O:53])[CH2:27][CH2:26]1)[C@:42]1([CH3:47])[CH2:41][CH2:40][C@H:39]2[C:38]([CH3:49])([CH3:48])[C:37](=[O:50])[CH:36]=[CH:35][C@:34]2([CH3:51])[C@H:33]1[CH2:32][CH2:31]3)=[CH2:22]

참가 물질

6

반응물 4

HCID 61680MAGNESIUM SILICATE (synthetic)HCID 72326BetulinHCID 517045Sodium AcetateHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 44559212Betulone Aldehyde수율 75%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a suspension of freshly activated powdered 4A molecular sieves (1.2 g), celite (1.2 g), florisil (1.2 g), sodium acetate (500 mg) and pyridinium chlorochromate (1.2 g) in CH2Cl2 (25 mL) add betulin (500 mg). The mixture is to be stirred for 2 hrs, and then filtered through a short column of silica gel. The filtrate is evaporated in vacuo. The residue is then subjected to column chromatography to afford betulone aldehyde (370 mg) as white solid.

후처리

  1. additionTo a suspension
  2. filtrationfiltered through a short column of silica gel
  3. customThe filtrate is evaporated in vacuo

출처 및 근거

ORD 기록
ord-1845d7038c7d4ac7a5d33fed45637898
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088757B2

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