Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → N-Methoxy-N-methyl-1H-indazole-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | Indazole-3-carboxylic acid | HCID 78250 | — |
| 반응물 | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-Methoxy-N-methyl-1H-indazole-3-carboxamide | HCID 16036867 | 69.1% |
반응 단계
In a round-bottomed flask, 4.0 g of 1H-indazole-3-carboxylic acid, 2.6 g of N,O-dimethylhydroxylamine hydrochloride, 9.4 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 8.4 ml of pyridine are placed in 120 ml of tetrahydrofuran. The mixture is stirred at ambient temperature for 20 h. The mixture is concentrated and the residue is taken up in water. The yellow precipitate obtained is washed with water and then dried under reduced pressure. 3.5 g of compound are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08088765B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-9738909b5b2b4a118505adb3bac6ad7f |
| 출처 메모 | uspto-grants-2012_01 |