Piperidine, 4-(1,1-dimethylethyl)- → 4-[4-(tert-Butyl)piperidin-1-yl]-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile

HRID 414982

반응식

HRID 414982 반응식
CS[C:3]1[N:4]=[C:5]([CH2:12][C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[NH:6][C:7](=[O:11])[C:8]=1[C:9]#[N:10].[C:18]([CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)([CH3:21])([CH3:20])[CH3:19]>>[C:18]([CH:22]1[CH2:27][CH2:26][N:25]([C:3]2[N:4]=[C:5]([CH2:12][C:13]3[CH:17]=[CH:16][S:15][CH:14]=3)[NH:6][C:7](=[O:11])[C:8]=2[C:9]#[N:10])[CH2:24][CH2:23]1)([CH3:21])([CH3:20])[CH3:19]

참가 물질

3

반응물 2

HCID 74661Piperidine, 4-(1,1-dimethylethyl)-HCID 584079424-(Methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile

생성물 1

HCID 1359949914-[4-(tert-Butyl)piperidin-1-yl]-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile

실험 절차

In analogy to the preparation of Example 1, 100 mg (0.38 mmol) of 4-(methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile are reacted with 536 mg (3.80 mmol) of 4-tert-butylpiperidine to give 57 mg (42% of theory) of the title compound.

출처 및 근거

ORD 기록
ord-cbfe5ed99dbd4ccb873ed01a5a53db2b
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088769B2

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