Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methyl-5-(2-methyl-4-nitrophenoxy)pyridine → 3-Methyl-4-((6-methylpyridin-3-yl)oxy)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methyl-5-(2-methyl-4-nitrophenoxy)pyridine | HCID 17990102 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-Methyl-4-((6-methylpyridin-3-yl)oxy)aniline | HCID 11424434 | 87.2% |
반응 단계
A mixture of 2-methyl-5-(2-methyl-4-nitro-phenoxy)-pyridine (11.5 g, 47.1 mmol) and palladium on carbon (300 mg, 10 wt. %, wet) in MeOH (200 mL) was flashed with hydrogen. A hydrogen balloon was then applied to the reaction mixture. The reaction was stirred for 2 hours and the solution was filtered through a pad of celite, and the pad was washed with MeOH (300 mL). Concentration of the solution gave crude product (8.8 g, 87%) as light yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08088766B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-9194d436cccf4778be18741d4c66f30f |
| 출처 메모 | uspto-grants-2012_01 |