Piperidine → HCID 178486868, 화합물

HRID 415016

반응식

HRID 415016 반응식
[NH:1]1CCCC[CH2:2]1.[NH2:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[C:14]([OH:19])=[CH:13][C:9]=1[C:10](O)=[O:11].N1C=CC=NN=1>CO>[CH3:18][O:17][C:15]1[CH:16]=[C:8]2[C:9]([C:10]([OH:11])=[N:1][CH:2]=[N:7]2)=[CH:13][C:14]=1[OH:19]

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 1230471,2,3-TriazineHCID 198070282-Amino-5-hydroxy-4-methoxybenzoic acid

생성물 1

HCID 178486868HCID 178486868, 화합물수율 107.1%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
0 °C

실험 절차

Piperidine (3 mL, 31 mmol) was added to a mixture of 2-Amino-5-hydroxy-4-methoxy-benzoic acid (8.1 g, 44.26 mmol) and triazine (5.38 g, 66.4 mmol) in MeOH (60 mL). The reaction was then heated to reflux and stir for 6 hours. The reaction was cool to 0° C. The product was isolated by filtration and washed with cold MeOH to give 6.37 g (33.2 mmol, 75%) of desired product.

후처리

  1. temperatureThe reaction was then heated
  2. temperatureto reflux
  3. customThe product was isolated by filtration
  4. washwashed with cold MeOH

출처 및 근거

ORD 기록
ord-f0d62225581f45c8a0294bae9c5fb353
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088766B2

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