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Water → Tert-butyl 4-(2-(4-amino-3-nitrophenoxy)ethyl)piperazine-1-carboxylate

HRID 415112
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HRID 415112 반응식
Br[CH2:2][CH2:3][O:4][C:5]1[CH:11]=[CH:10][C:8]([NH2:9])=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1.[C:15]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16].O>C1COCC1>[NH2:9][C:8]1[CH:10]=[CH:11][C:5]([O:4][CH2:3][CH2:2][N:25]2[CH2:24][CH2:23][N:22]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:27][CH2:26]2)=[CH:6][C:7]=1[N+:12]([O-:14])=[O:13]
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참가 물질

5

반응물 3

HCID 962WaterHCID 143452tert-Butyl piperazine-1-carboxylateHCID 154854442-(4-Amino-3-nitrophenoxy)ethyl bromide

생성물 1

HCID 66623212Tert-butyl 4-(2-(4-amino-3-nitrophenoxy)ethyl)piperazine-1-carboxylate수율 59%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A 100 mL flask was charged with 4-(2-bromoethoxy)-2-nitroaniline (2.2 g, 8.4 mmol) in THF (20 mL) and 4-N-boc-piperazine (1.56 g, 8.4 mmol) was added and stirred at room temperature. The reaction was monitored by LCMS. After 30 minutes, the reaction mixture was treated with deionized water (100 mL) and sonicated. The resulting solid was collected by filtration and dried at reduced pressure to give 1.75 g of tert-butyl 4-(2-(4-amino-3-nitrophenoxy)ethyl)piperazine-1-carboxylate (59% yield). MS (EI): 367 (MH+).

후처리

  1. additionwas added
  2. customsonicated
  3. filtrationThe resulting solid was collected by filtration
  4. customdried at reduced pressure

출처 및 근거

ORD 기록
ord-2163b878118b4730aaa515d2f64ed6ed
출처 데이터셋
uspto-grants-2012_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08088767B2

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