2-Chloro-6-nitroaniline → (2-Amino-3-chlorophenyl)amine

HRID 415127

반응식

HRID 415127 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-])=O)[C:3]=1[NH2:4]>CO.[Pd]>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([NH2:9])[C:3]=1[NH2:4]

참가 물질

4

반응물 1

HCID 698552-Chloro-6-nitroaniline

생성물 1

HCID 3462489(2-Amino-3-chlorophenyl)amine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 2-chloro-6-nitroaniline (1.0 g, 5.81 mmol, commercially available from Apollo International) in methanol (20 mL) was passed through the H-Cube® (Thales Nanotechnology Inc.) operating at 40 bars and ambient temperature with a flow rate of 1 mL/min. The H-Cube® was equipped with a 10% Pd/C cartridge (Catcart™). The reaction mixture was collected and concentrated after being exposed to the hydrogenation conditions. The crude 3-chlorobenzene-1,2-diamine was carried on without further purification. MS (EI): 145 (MH+).

후처리

  1. customoperating at 40 bars and ambient temperature with a flow rate of 1 mL/min
  2. customThe reaction mixture was collected
  3. concentrationconcentrated
  4. customThe crude 3-chlorobenzene-1,2-diamine was carried on without further purification

출처 및 근거

ORD 기록
ord-a26d6681ebd64b5e8fe0c6f6932def1e
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088767B2

연결된 노트

불러오는 중…