Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-Hydroxy-2-nitrobenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 3-Chloro-2-nitrobenzoic acid | HCID 20902 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Hydroxy-2-nitrobenzoic acid | HCID 293291 | 150.2% |
반응 단계
A mixture of 3-chloro-2-nitrobenzoic acid (40 g, 0.20 mol) and KOH (160 g, 2.86 mol) in water (200 mL) was heated to reflux for 16 hr. 6N aqueous hydrochloric acid was added to the mixture to pH=3, then extracted with ethyl acetate (500 mL×4). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and concentrated to give 3-hydroxy-2-nitrobenzoic acid (55 g), LC-MS (ESI) m/z 184 [M+1]−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08088760B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-f5de328daff54048ac75d1f6e3803ac8 |
| 출처 메모 | uspto-grants-2012_01 |