Hydrochloric Acid → 3-Hydroxy-2-nitrobenzoic acid

HRID 415161

반응식

HRID 415161 반응식
Cl[C:2]1[C:3]([N+:11]([O-:13])=[O:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[OH-:14].[K+].Cl>O>[OH:14][C:2]1[C:3]([N+:11]([O-:13])=[O:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 209023-Chloro-2-nitrobenzoic acid

생성물 1

HCID 2932913-Hydroxy-2-nitrobenzoic acid수율 150.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 3-chloro-2-nitrobenzoic acid (40 g, 0.20 mol) and KOH (160 g, 2.86 mol) in water (200 mL) was heated to reflux for 16 hr. 6N aqueous hydrochloric acid was added to the mixture to pH=3, then extracted with ethyl acetate (500 mL×4). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and concentrated to give 3-hydroxy-2-nitrobenzoic acid (55 g), LC-MS (ESI) m/z 184 [M+1]−.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 16 hr
  3. extractionextracted with ethyl acetate (500 mL×4)
  4. washThe combined organic layers were washed with brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f5de328daff54048ac75d1f6e3803ac8
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088760B2

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