Triethylamine → 2,5-dichloro-N-(5-methoxy-1H-pyrazol-3-yl)pyrimidin-4-amine

HRID 415427노트

반응식

HRID 415427 반응식
[CH3:1][O:2][C:3]1[NH:7][N:6]=[C:5]([NH2:8])[CH:4]=1.C(N(CC)CC)C.[Cl:16][C:17]1[N:22]=[C:21](Cl)[C:20]([Cl:24])=[CH:19][N:18]=1>CCO>[Cl:16][C:17]1[N:22]=[C:21]([NH:8][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[NH:7][N:6]=2)[C:20]([Cl:24])=[CH:19][N:18]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 2372592,4,5-TrichloropyrimidineHCID 178493288HCID 178493288, 화합물

생성물 1

HCID 1784930722,5-dichloro-N-(5-methoxy-1H-pyrazol-3-yl)pyrimidin-4-amine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 5-methoxy-1H-pyrazol-3-amine (890 mg, 7.8 mmol) in absolute EtOH (20 ml) was added triethylamine (3.3 ml, 23.6 mmol) and 2,4,5-trichloropyrimidine (1.4 g, 7.8 mmol) and the resulting solution was aged at room temperature for 12 hours. The mixture was partitioned between EtOAc and H2O, the organic layer was washed with brine and dried. The solvents were removed under reduced pressure to give the title compound as an oil which crystallized upon standing (1.8 g). m/z: 261.

후처리

  1. customThe mixture was partitioned between EtOAc and H2O
  2. washthe organic layer was washed with brine
  3. customdried
  4. customThe solvents were removed under reduced pressure

출처 및 근거

ORD 기록
ord-12429812cce247c59750ceefeb7103e9
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088784B2

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