2,4,5,6-Tetrachloropyrimidine → HCID 178493073, 화합물

HRID 415441

반응식

HRID 415441 반응식
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([Cl:9])=[C:4](Cl)[N:3]=1.Cl.[CH3:12][O:13][C:14]1[NH:18][N:17]=[C:16]([NH2:19])[CH:15]=1>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([NH:19][C:16]2[CH:15]=[C:14]([O:13][CH3:12])[NH:18][N:17]=2)[C:5]([Cl:9])=[C:6]([Cl:8])[N:7]=1

참가 물질

4

반응물 2

HCID 156902,4,5,6-TetrachloropyrimidineHCID 178493289HCID 178493289, 화합물

생성물 1

HCID 178493073HCID 178493073, 화합물수율 25.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2,4,5,6-tetrachloro-pyrimidine (2.18 g) in absolute ethanol (100 mL) was added DIEPA (4.4 mL) and 5-methoxy-1H-pyrazol-3-amine hydrogen chloride salt (1.50 g). The resulting solution was stirred at room temperature for over night. The solvent was evaporated under reduced pressure. The crude compound was purified by Gilson (10-60% MeCN/H2O, 15 minutes) to give the titled compound as solid (0.76 g). m/z 294.

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. customThe crude compound was purified by Gilson (10-60% MeCN/H2O, 15 minutes)

출처 및 근거

ORD 기록
ord-31b3bb9ac5eb443390e029345ae3ca5f
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088784B2

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