Ammonia → HCID 178508170, 화합물

HRID 415487노트

반응식

HRID 415487 반응식
[Si]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:25]2[C:24]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[N:18]=[C:17](Cl)[C:16]=2[N:15]=[C:14]1[OH:27])(C(C)(C)C)(C)C.[NH3:28]>CO>[NH2:28][C:17]1[C:16]2[N:15]=[C:14]([OH:27])[N:13]([CH2:12][CH2:11][CH2:10][CH2:9][OH:8])[C:25]=2[C:24]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N:18]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 178455216HCID 178455216, 화합물

생성물 1

HCID 178508170HCID 178508170, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

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온도
150 °C

실험 절차

1-[4-(tert-Butyldimethylsilanyloxy)butyl]-4-chloro-1H-imidazo[4,5-c]quinolin-2-ol (5.0 g, 12 mmol) and ammonia (200 mL of a 7 N solution in methanol) were added to a high-pressure vessel, which was sealed and heated in an oven at 150° C. for five days, allowed to cool, and concentrated under reduced pressure. The crude product was triturated with hexane for 15 minutes, and the resulting solid was isolated by filtration, washed with hexane (500 mL), and dried under vacuum to provide 3.53 g of 4-amino-1-(4-hydroxybutyl)-1H-imidazo[4,5-c]quinolin-2-ol as a light gray solid.

후처리

  1. customwhich was sealed
  2. temperatureto cool
  3. concentrationconcentrated under reduced pressure
  4. customThe crude product was triturated with hexane for 15 minutes
  5. customthe resulting solid was isolated by filtration
  6. washwashed with hexane (500 mL)
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-8a6849a814904b9eb4a98384fead7d9a
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088790B2

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