Thionyl Chloride → HCID 178508169, 화합물

HRID 415488노트

반응식

HRID 415488 반응식
S(Cl)([Cl:3])=O.[NH2:5][C:6]1[C:15]2[N:16]=[C:17]([OH:24])[N:18]([CH2:19][CH2:20][CH2:21][CH2:22]O)[C:14]=2[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N:7]=1>ClCCCl>[NH2:5][C:6]1[C:15]2[N:16]=[C:17]([OH:24])[N:18]([CH2:19][CH2:20][CH2:21][CH2:22][Cl:3])[C:14]=2[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N:7]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 178508170HCID 178508170, 화합물

생성물 1

HCID 178508169HCID 178508169, 화합물수율 85.7%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

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온도
50 °C

실험 절차

Thionyl chloride (1.1 mL, 15 mmol) was added to a solution of 4-amino-1-(4-hydroxybutyl)-1H-imidazo[4,5-c]quinolin-2-ol (3.5 g, 13 mmol) in 1,2-dichloroethane (60 mL), and the reaction was stirred at 50° C. overnight. A solid was present, which was collected by filtration and washed with diethyl ether (500 to 600 mL) to provide 3.24 g of 4-amino-1-(4-chlorobutyl)-1H-imidazo[4,5-c]quinolin-2-ol as a light gray solid.

후처리

  1. filtrationwhich was collected by filtration
  2. washwashed with diethyl ether (500 to 600 mL)

출처 및 근거

ORD 기록
ord-be8c1221c1d84d2dbe3e5ec5dec9967f
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088790B2

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