4-Bromobutyryl chloride → HCID 66620617, 화합물

HRID 415505노트

반응식

HRID 415505 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[NH2:12].[Br:13][CH2:14][CH2:15][CH2:16][C:17](Cl)=[O:18]>ClCCCl.ClCCl>[Br:13][CH2:14][CH2:15][CH2:16][C:17]([NH:12][C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[Cl:1])=[CH:10][CH:9]=[CH:8][CH:7]=2)=[O:18]

참가 물질

5

반응물 2

HCID 702254-Bromobutyryl chlorideHCID 8173324-chloroquinolin-3-amine

생성물 1

HCID 66620617HCID 66620617, 화합물수율 53.7%

시약·촉매·용매 2

HCID 111,2-Dichloroethane용매HCID 6344Dichloromethane용매

실험 절차

A solution of 4-chloroquinolin-3-amine (3.70 g, 20.74 mmol) and 4-bromobutyryl chloride (11.54 g, 62.22 mmol) dissolved in 100 mL of 1,2-dichloroethane was heated to reflux. After 17 hours the reaction was cooled to room temperature, diluted with dichloromethane, washed with saturated aqueous K2CO3, H2O and brine, dried over Na2SO4, and concentrated under reduced pressure to give a brown solid. The solid was triturated with a mixture of hexane and ether, filtered and dried to give 4-bromo-N-(4-chloroquinolin-3-yl)butanamide (3.65 g) as a brown solid.

후처리

  1. temperaturewas heated to reflux
  2. washwashed with saturated aqueous K2CO3, H2O and brine
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated under reduced pressure
  5. customto give a brown solid
  6. customThe solid was triturated with a mixture of hexane and ether
  7. filtrationfiltered
  8. customdried

출처 및 근거

ORD 기록
ord-381d956fffe049c08628c1c6ebe05d7e
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088788B2

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