6-Chloro-2-benzothiazolamine → 3-[(6-Chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluorobenzenecarboxamide

HRID 415618

반응식

HRID 415618 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7](N)[S:8][C:4]=2[CH:3]=1.C([CH2:14][O:15][C:16]1[C:17]([F:26])=[C:18]([C:23]([NH2:25])=[O:24])[C:19]([F:22])=[CH:20][CH:21]=1)#N>>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([CH2:14][O:15][C:16]3[C:17]([F:26])=[C:18]([C:23]([NH2:25])=[O:24])[C:19]([F:22])=[CH:20][CH:21]=3)[S:8][C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 72266-Chloro-2-benzothiazolamineHCID 594028043-(Cyanomethoxy)-2,6-difluorobenzenecarboxamide

생성물 1

HCID 462371393-[(6-Chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluorobenzenecarboxamide수율 38%

실험 절차

Synthesised from 6-chloro-1,3-benzothiazol-2-amine and 3-(cyanomethoxy)-2,6-difluorobenzene carboxamide, according to Method K, scheme 26. Yield 38% (second step), mp 190-191° C., HPLC-MS (method 1): m/z 355 [M+H]+, Rt=3.85 min.

출처 및 근거

ORD 기록
ord-b46349a9f1e640b98d4e7cf12a1b7d27
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088791B2

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