Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Riluzole → 2,6-Difluoro-3-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]methoxybenzenecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Riluzole | HCID 5070 | — |
| 반응물 | 3-(Cyanomethoxy)-2,6-difluorobenzenecarboxamide | HCID 59402804 | — |
| 생성물 | 2,6-Difluoro-3-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]methoxybenzenecarboxamide | HCID 59403008 | 34% |
반응 단계
Synthesised from 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine and 3-(cyanomethoxy)-2,6-difluorobenzenecarboxamide, according to Method K, scheme 26. Yield 34% (second step), mp 174-175° C., HPLC-MS (method 1): m/z 405 [M+H]+, Rt=4.14 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08088791B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-ddfeff4a76e3470eb7fe88425a49938d |
| 출처 메모 | uspto-grants-2012_01 |