3-Chloro-2-butanone → 2-(4-Methoxy-phenyl)-4,5-dimethyl-oxazole

HRID 415644

반응식

Cl[CH:2]([CH3:6])[C:3](=O)[CH3:4].[CH3:7][O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][CH:10]=1>>[CH3:7][O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]2[O:14][C:2]([CH3:6])=[C:3]([CH3:4])[N:15]=2)=[CH:11][CH:10]=1

참가 물질

반응물 2

HCID 200263-Chloro-2-butanone

HCID 769594-Methoxybenzamide

생성물 1

HCID 189829612-(4-Methoxy-phenyl)-4,5-dimethyl-oxazole수율 83.6%

반응 조건

온도: 115 °C

실험 절차

A mixture of 3-Chloro-2-butanone (2.1 g, 10.0 mmol) and 4-methoxybenzamide (0.30 g, 1.0 mmol) was heated at 115° C. for 15 h under nitrogen atmosphere. After the completion of the reaction mixture (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure and the residue was purified over silica gel (230-400 M, 20% EtOAc-Hexane) to get the desired product (0.17 g, 42%) as a white solid. The corresponding chloro derivative was also prepared by the same general method.

후처리

customAfter the completion of the reaction mixture (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure
customthe residue was purified over silica gel (230-400 M, 20% EtOAc-Hexane)

출처 및 근거

ORD 기록: ord-4e6f58dfdbb14c099a1365cfb18d06ec
출처 데이터셋: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08088791B2

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