N-(4-Phenoxyphenyl)acetamide → N-(4-Phenoxy-phenyl)-thioacetamide

HRID 415691노트

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HRID 415691 반응식
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=O)[CH3:16])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:27])=CC=1>C1(C)C=CC=CC=1>[O:1]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[S:27])[CH3:16])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 80579N-(4-Phenoxyphenyl)acetamideHCID 87949Lawesson's reagent

생성물 1

HCID 59402779N-(4-Phenoxy-phenyl)-thioacetamide수율 86.6%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
120 °C

실험 절차

To a solution of N-(4-phenoxy-phenyl)-acetamide (1.20 g, 5.28 mmol) in 10 ml of toluene was added Lawesson's reagent (1.50 g, 3.70 mmol). The reaction mixture was heated at 120° C. for 2 h. After the completion of the reaction (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure. The residue was purified by column chromatography on silica (60-120 M) using ethyl acetate/hexane (5:95) as the eluent to provide the title compound (0.78 g, 60.7%).

후처리

  1. customAfter the completion of the reaction (TLC monitoring)
  2. customthe reaction mixture was evaporated to dryness under reduced pressure
  3. customThe residue was purified by column chromatography on silica (60-120 M)

출처 및 근거

ORD 기록
ord-cc3353eea604427f8b44b4cc35467b22
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088791B2

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