5-Amino-2-fluorobenzonitrile → HCID 178495899, 화합물

HRID 415844

반응식

HRID 415844 반응식
[OH:1][N:2]=[C:3](Cl)[C:4]1[C:8]([NH:9][CH2:10][CH2:11][O:12][CH3:13])=[N:7][O:6][N:5]=1.[NH2:15][C:16]1[CH:17]=[CH:18][C:19]([F:24])=[C:20]([CH:23]=1)[C:21]#[N:22]>>[C:21]([C:20]1[CH:23]=[C:16]([NH:15][C:3]([C:4]2[C:8]([NH:9][CH2:10][CH2:11][O:12][CH3:13])=[N:7][O:6][N:5]=2)=[N:2][OH:1])[CH:17]=[CH:18][C:19]=1[F:24])#[N:22]

참가 물질

3

반응물 2

HCID 27376735-Amino-2-fluorobenzonitrile2회HCID 136330165N-Hydroxy-4-[(2-methoxyethyl)amino]-1,2,5-oxadiazole-3-carboximidoyl chloride

생성물 1

HCID 178495899HCID 178495899, 화합물수율 100%

실험 절차

The desired compound was prepared according to the procedure of Example 13, step A, using N-hydroxy-4-[(2-methoxyethyl)amino]-1,2,5-oxadiazole-3-carboximidoyl chloride [made according to Example 1, steps A through E] and 5-amino-2-fluorobenzonitrile [Aldrich, product #639877] as the starting materials in 100% yield. LCMS for C13H14FN6O3 (M+H)+: m/z=321.0.

출처 및 근거

ORD 기록
ord-7867f7f23b734657bf01ab8fbf679e0d
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088803B2

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