Diphenyl Ether → Thieno(3,2-b)pyridin-7-ol
반응식
CC1(C)O[C:6](=[O:8])[C:5](=[CH:9][NH:10][C:11]2[CH:15]=[CH:14][S:13][CH:12]=2)C(=O)O1.C1(OC2C=CC=CC=2)C=CC=CC=1>CC(OC)(C)C>[S:13]1[C:12]2[C:11](=[N:10][CH:9]=[CH:5][C:6]=2[OH:8])[CH:15]=[CH:14]1참가 물질
4
실험 절차
A 200-mL rb flask was charged with 2,2-dimethyl-5-((thiophen-3-ylamino)methylene)-1,3-dioxane-4,6-dione (6.73 g, 26.6 mmol) and diphenyl ether (25 mL) and heated to about 200 deg C. for about 30-45 min and the mixture was allowed to cool to rt overnight. The mixture was scraped down with a spatula and diluted with MTBE. The mixture was filtered through paper and washed with MTBE. The brown solid was air dried to yield thieno[3,2-b]pyridin-7-ol.
후처리
- temperatureheated to about 200 deg C
- filtrationThe mixture was filtered through paper
- washwashed with MTBE
- customdried
출처 및 근거
- ORD 기록
- ord-4713f4b7f0a749d6b58d3eab6ea48c2d
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08088794B2
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