Water → 2-Aminocarbonylamino-4-chloro-5-(2-naphthyl)pyrrole-3-carboxamide

HRID 416030노트

반응식

HRID 416030 반응식
[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]([C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3].[Cl:23]N1C(=O)CCC1=O.O>CN(C)C=O>[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]([C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)=[C:8]([Cl:23])[C:9]=1[C:10]([NH2:12])=[O:11])=[O:3]

참가 물질

5

반응물 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 461809882-Aminocarbonylamino-5-(2-naphthyl)pyrrole-3-carboxamide

생성물 1

HCID 582940372-Aminocarbonylamino-4-chloro-5-(2-naphthyl)pyrrole-3-carboxamide수율 45%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 2-aminocarbonylamino-5-(2-naphthyl)pyrrole-3-carboxamide (Compound No. 1-1, 92 mg, 0.31 mmol) and N-chlorosuccinimide (46 mg, 0.34 mmol) in anhydrous N,N-dimethylformamide (2 mL) was stirred at 60° C. for 2 hours. After cooling, water (10 mL) was added thereto, the precipitated solid was filtered off, and washed with water (10 mL) and acetone (10 mL). The obtained solid was dried at 50° C. under reduced pressure to give the target compound (46 mg) as a pale brown solid (Yield 45%).

후처리

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid was filtered off
  3. washwashed with water (10 mL) and acetone (10 mL)
  4. customThe obtained solid was dried at 50° C. under reduced pressure

출처 및 근거

ORD 기록
ord-1cf96be556f44b5ba843c18e3f773bd9
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088817B2

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