Morpholine → 4-(6-Chloropyridazin-3-yl)morpholine

HRID 416235노트

반응식

HRID 416235 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=1>>[Cl:7][C:8]1[N:9]=[N:10][C:11]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:12][CH:13]=1

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 673313,6-Dichloropyridazine

생성물 1

HCID 3210794-(6-Chloropyridazin-3-yl)morpholine수율 79.1%

반응 조건

온도
90 °C

실험 절차

A 50 mL flask equipped with a reflux condenser was charged with morpholine (2.93 mL, 33.5 mmol) and 3,6-dichloropyridazine (5.00 g, 33.5 mmol). The mixture was heated at 90° C. for 6 h, the resultant solid was partitioned between EtOAc, water and saturated NH4Cl. Organic layer was separated, dried over anhydrous Na2SO4, filtered, and evaporated to afford the title compound 64 (5.3 g, 26.5 mmol, 79% yield).

후처리

  1. customA 50 mL flask equipped with a reflux condenser
  2. customthe resultant solid was partitioned between EtOAc, water and saturated NH4Cl
  3. customOrganic layer was separated
  4. dry with materialdried over anhydrous Na2SO4
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-347ec66b98f74d89a732af63a249016c
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088805B2

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