(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one → 4-((4-(2-(Tert-butoxycarbonylamino)-4-methylthiazol-5-yl)-pyrimidin-2-ylamino)methyl)benzoic acid

참여 물질

역할	이름	HCID	투입량
반응물	(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one	HCID 5825354	—
반응물	(E)-1-[2-(Boc-Amino-)-4-methylthiazol-5-yl]-3-(dimethylamino)prop-2-en-1-one	HCID 58930506	—
반응물	4-[(4-Pyrazin-2-yl-pyrimidin-2-ylamino)-methyl]-benzoic acid	HCID 66622167	—
생성물	4-((4-(2-(Tert-butoxycarbonylamino)-4-methylthiazol-5-yl)-pyrimidin-2-ylamino)methyl)benzoic acid	HCID 58930474	18%

반응 단계

Following the procedure described for the synthesis of the acid 25a (scheme 6, step 3) but substituting enamino ketone 23a for the enamino ketone 338, title compound was obtained in 18% yield and was used for the next steps without further purification. MS (m/z): 441.50 (calc) 442.3 (MH+) (found).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08088805B2
출처 데이터셋	uspto-grants-2012_01
ORD ID	ord-aeeadea4a66a45d79c56970b509663a4
출처 메모	uspto-grants-2012_01