Hydrazine → Isoquinoline-3-carbohydrazide

HRID 416315

반응식

HRID 416315 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([O:13]C)=O)[N:2]=1.[NH2:15][NH2:16]>C(O)C>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([NH:15][NH2:16])=[O:13])[N:2]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 725374Methyl 3-isoquinolinecarboxylate

생성물 1

HCID 55263898Isoquinoline-3-carbohydrazide수율 86%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of methyl isoquinoline-3-carboxylate (10 g, 53.42 mmol) in ethanol (100 mL) was added hydrazine (17.1 g). The reaction mixture was refluxed for 30 min and concentrated under high vacuum to remove hydrazine. The resulting residue was triturated with ethanol (20 mL) to give isoquinoline-3-carbohydrazide (8.6 g, 86%). LRMS (M+H+) m/z 188.1.

후처리

  1. temperatureThe reaction mixture was refluxed for 30 min
  2. concentrationconcentrated under high vacuum
  3. customto remove hydrazine
  4. customThe resulting residue was triturated with ethanol (20 mL)

출처 및 근거

ORD 기록
ord-c74fdf04e1aa41209ea2a44cffdbc2bf
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088793B2

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