Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → 2-Iodo-6-methylpyridin-3-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 2-Methyl-5-hydroxypyridine | HCID 14275 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Iodo-6-methylpyridin-3-ol | HCID 89957 | 43.9% |
반응 단계
Sodium carbonate (68.0 g) and water (810 mL) were added to 5-hydroxy-2-methylpyridine (1-014-01) (36.11 g), and the reaction mixture was stirred at room temperature, dissolved. To the reaction mixture was added dropwise a solution of iodine (117 g) and potassium iodide (117 g) in water (810 mL) for 35 min. The resulting pink-yellow crystal was filtered and dried under reduced pressure to give 2-iodo-3-hydroxy-6-methylpyridine (2-014-01) (34.1 g, 43.9%, m.p. 187-190° C.)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08088924B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-a2e97d959c4e4dd8b6b848baa7230577 |
| 출처 메모 | uspto-grants-2012_01 |