Water → HCID 22266530, 화합물
반응식
Cl.N1C=CC=CC=1.[CH2:8]([N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18]C)[C:13]1=[S:20])[CH2:9][CH2:10][CH3:11].O>C(OCC)(=O)C>[CH2:8]([N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[C:13]1=[S:20])[CH2:9][CH2:10][CH3:11]참가 물질
5
반응 조건
- 온도
- 190 °C
실험 절차
Pyridine hydrochloride salt (3.6 g) was added to 1-butyl-3-methoxypyridine-2-thione (2-034-03) (1.4 g), and the reaction mixture was stirred at 190° C. for 40 min. To the reaction mixture were added water and ethyl acetate, and the organic layer was separated, and the organic layer was extracted three times with ethyl acetate. The combined organic layers were washed with water and brine, dried over anhydrous magnesium sulfate, and evaporated under reduced pressure to give 1-butyl-3-hydroxypyridine-2-thione (2-034-04) (1.02 g, 78%) as an oil.
후처리
- customthe organic layer was separated
- extractionthe organic layer was extracted three times with ethyl acetate
- washThe combined organic layers were washed with water and brine
- dry with materialdried over anhydrous magnesium sulfate
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-ded6cecd47e948efa1a53f4945bd4d4c
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08088924B2
반응 노트
불러오는 중…