Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → HCID 178478269, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | HCID 178452227 | HCID 178452227 | — |
| 반응물 | HCID 178509626 | HCID 178509626 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178478269 | HCID 178478269 | 49% |
반응 단계
This was prepared using the same procedure as for (4-(6-bromo-7-(4-(pyridin-3-ylmethyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine, but here using tert-butyl 4-(4-(6-chloro-7-(4-(pyridin-3-ylmethyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)piperazine-1-carboxylate (10 mg, 0.0169 mmol), TFA (0.25 mL) and CH2Cl2 (1 mL). The same purification procedure gave the desired product (4 mg, 49%) as a pale yellow solid;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08088761B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-9b5f18a19ace40c9b6b0d38a296d07c6 |
| 출처 메모 | uspto-grants-2012_01 |