Water → 1-(4-Bromophenyl)-4-(methylsulfonyl)piperazine

HRID 41691노트

반응식

HRID 41691 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[Br:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:9][CH:8]=1.C(N(CC)CC)C.O>ClCCl>[Br:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[CH2:18][CH2:17][N:16]([S:2]([CH3:1])(=[O:4])=[O:3])[CH2:15][CH2:14]2)=[CH:11][CH:12]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 27356291-(4-Bromophenyl)piperazine

생성물 1

HCID 219193841-(4-Bromophenyl)-4-(methylsulfonyl)piperazine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

7.7 ml of methanesulphonyl chloride are added to a solution of 20 g of 1-(4-bromophenyl)piperazine and 17.34 ml of triethylamine in 394 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 4 h. Water is subsequently added and the organic phase is washed twice with water and dried over magnesium sulphate and then the solvent is evaporated under reduced pressure to result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine. The product is subsequently used as is without other purification.

후처리

  1. washthe organic phase is washed twice with water
  2. dry with materialdried over magnesium sulphate
  3. customthe solvent is evaporated under reduced pressure
  4. customto result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine
  5. customas is without other purification

출처 및 근거

ORD 기록
ord-8a371fbe6a20430eabf750398e20cf7a
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530657B2

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