Di-tert-butyl azodicarboxylate → HCID 66619454, 화합물

HRID 417083

반응식

HRID 417083 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH:13]([CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:14][OH:15])[C:11]3[CH:22]=[CH:23][CH:24]=[CH:25][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.[CH3:26][O:27][C:28](=[O:37])[C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([F:35])[C:30]=1O.N(C(OC(C)(C)C)=O)=NC(OC(C)(C)C)=O>>[CH3:26][O:27][C:28](=[O:37])[C:29]1[CH:34]=[CH:33][C:32]([O:15][CH2:14][CH:13]([N:12]2[C:11]3[CH:22]=[CH:23][CH:24]=[CH:25][C:10]=3[N:9]=[C:8]2[C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[C:31]([F:35])[CH:30]=1

참가 물질

4

반응물 3

HCID 97268Di-tert-butyl azodicarboxylateHCID 573875Methyl 3-fluoro-2-hydroxybenzoateHCID 666194992-[2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-2-cyclohexyl-ethanol

생성물 1

HCID 66619454HCID 66619454, 화합물

실험 절차

The title compound was prepared in analogy to Example 4, intermediate, from 2-[2-(4-chloro-phenyl)-benzoimidazol-1-yl]-2-cyclohexyl-ethanol and 3-fluoro-hydroxy-benzoic acid methyl ester (commercially available) and replacing di-ethyl azodicarboxylate by di-tert-butyl azodicarboxylate. White solid (91%). MS (Turbo Spray): m/z=507.3 [M+H].

출처 및 근거

ORD 기록
ord-c9ffbcd1a70b4140a8d1320b5c634441
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088930B2

연결된 노트

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