Methyl 3-(methylamino)-4-nitrobenzoate → Methyl 4-amino-3-(methylamino)benzoate

HRID 417323노트

반응식

HRID 417323 반응식
[CH3:1][NH:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[N+:13]([O-])=O)[C:6]([O:8][CH3:9])=[O:7]>C(OCC)(=O)C.[Pd]>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:12]([NH2:13])=[C:3]([NH:2][CH3:1])[CH:4]=1

참가 물질

4

반응물 1

HCID 15892779Methyl 3-(methylamino)-4-nitrobenzoate

생성물 1

HCID 57835341Methyl 4-amino-3-(methylamino)benzoate수율 93%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A suspension of methyl 3-(methylamino)-4-nitrobenzoate (Bionet) (0.5 g, 2.4 mmol) and Pd/C (Aldrich, 10%, 0.1 g) in ethyl acetate (7 mL) was vigorously shaken in a Parr under atmosphere of H2 (50 psi) for 0.5 h. The mixture was filtered through a short pad of celite. The filtrate was concentrated to give 4-amino-3-methylamino-benzoic acid methyl ester as a dark brown foam (0.4 g, 93%).

후처리

  1. filtrationThe mixture was filtered through a short pad of celite
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-1129d4435c914483a9ae61e22fa7d89f
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088815B2

반응 노트

불러오는 중…