Monoethyl malonate → HCID 178516628, 화합물

HRID 41754

반응식

HRID 41754 반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[F:11][CH:12]([F:25])[CH2:13][CH2:14][CH2:15][O:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=O)=[CH:19][CH:18]=1.C([O:28][C:29]([CH2:31][C:32](O)=[O:33])=O)C.C(=O)(OC)OC(C)(C)C[N+]#[C-].CC(C)([O-])C.[Na+]>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:21]([C:20]4[CH:23]=[CH:24][C:17]([O:16][CH2:15][CH2:14][CH2:13][CH:12]([F:25])[F:11])=[CH:18][CH:19]=4)[C:29](=[O:28])[CH2:31][C:32]3=[O:33])=[CH:9][C:4]=2[N:3]=[CH:2]1

참가 물질

6

반응물 5

HCID 70615Monoethyl malonateHCID 23676156Sodium t-butoxideHCID 252674641-Isocyano-2-methylpropan-2-yl methyl carbonateHCID 866708784-(4,4-Difluorobutoxy)benzaldehydeHCID 178507353HCID 178507353, 화합물

생성물 1

HCID 178516628HCID 178516628, 화합물

실험 절차

The compound was synthesized starting from 1H-benzo[d]imidazol-5-amine (0.620 g, 4.6 mmol), 4-(4,4-difluorobutoxy)benzaldehyde (1.0 g, 4.6 mmol), 2-(ethoxycarbonyl)acetic acid (0.61 g, 4.6 mmol), 1-isocyano-2-methylpropan-2-yl methyl carbonate (0.72 g, 4.6 mmol) and sodium tert.-butoxide (0.620 g, 5.5 mmol) according to method 3.

후처리

  1. customThe compound was synthesized

출처 및 근거

ORD 기록
ord-731d65a87baf4c80a320719dc821f47c
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530670B2

연결된 노트

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