Potassium Carbonate → HCID 178516340, 화합물

HRID 41778

반응식

HRID 41778 반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:14]([C:15]4[CH:20]=[CH:19][C:18]([N:21]5[CH2:26][CH2:25][O:24][CH2:23][CH2:22]5)=[CH:17][CH:16]=4)[C:13](O)=[CH:12][C:11]3=[O:28])=[CH:9][C:4]=2[N:3]=[CH:2]1.Cl.[F:30][C:31]1([F:37])[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1.C([O-])([O-])=O.[K+].[K+]>C1(C)C=CC=CC=1.CN(C=O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:14]([C:15]4[CH:16]=[CH:17][C:18]([N:21]5[CH2:26][CH2:25][O:24][CH2:23][CH2:22]5)=[CH:19][CH:20]=4)[C:13]([N:34]4[CH2:35][CH2:36][C:31]([F:37])([F:30])[CH2:32][CH2:33]4)=[CH:12][C:11]3=[O:28])=[CH:9][C:4]=2[N:3]=[CH:2]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 27583514,4-Difluoropiperidine hydrochlorideHCID 178516575HCID 178516575, 화합물

생성물 1

HCID 178516340HCID 178516340, 화합물

시약·촉매·용매 1

HCID 21735183Dimethylformamide toluene용매

실험 절차

The compound was synthesized starting from 1-(1H-benzo[d]imidazol-5-yl)-4-hydroxy-5-(4-morpholinophenyl)-1H-pyrrol-2(5H)-one (1.0 g, 2.65 mmol), 4,4-difluoropiperidine hydrochloride (0.800 g, 5.1 mmol) and K2CO3 (0.73 g, 5.3 mmol) in toluene/DMF (2:1; 15 ml) according to method 8a described above.

후처리

  1. customThe compound was synthesized

출처 및 근거

ORD 기록
ord-7083fea5a4464f51be27cf64c9566bdf
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530670B2

연결된 노트

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