2-Bromo-5-fluorotoluene → 4-Fluoro-2-methylbenzonitrile
반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH3:9].[C:10]([Cu])#[N:11]>CN(C=O)C.O>[F:8][C:5]1[CH:6]=[CH:7][C:2]([C:10]#[N:11])=[C:3]([CH3:9])[CH:4]=1참가 물질
5
실험 절차
A mixture of 2-bromo-5-fluorotoluene (2) (3.5 g, 18.5 mmol) and CuCN (2 g, 22 mmol) in DMF (100 mL) was refluxed for 24 hours. The reaction was diluted with water and extracted with hexane. The organics were dried over MgSO4 and the solvent removed to give product 3 (yield 60%). 1H-NMR (400 MHz, CDCl3): δ 7.60 (dd, J=5.6, 8.8 Hz, 1H), 6.93-7.06 (m, 2H), 2.55 (s, 3H).
후처리
- temperaturewas refluxed for 24 hours
- extractionextracted with hexane
- dry with materialThe organics were dried over MgSO4
- customthe solvent removed
출처 및 근거
- ORD 기록
- ord-cf5b6213d93942519cca961bdd767c9f
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08093236B2
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