Tert-Butylamine → Tert-butyl-pent-4-ynyl-amine

반응식

I[CH2:2][CH2:3][CH2:4][C:5]#[CH:6].[C:7]([NH2:11])([CH3:10])([CH3:9])[CH3:8]>>[C:7]([NH:11][CH2:2][CH2:3][CH2:4][C:5]#[CH:6])([CH3:10])([CH3:9])[CH3:8]

참가 물질

반응물 2

HCID 6385Tert-Butylamine

HCID 110197205-Iodo-1-pentyne

생성물 1

HCID 57713825Tert-butyl-pent-4-ynyl-amine

실험 절차

A solution of 5-iodo-pent-1-yne (1.0 g, 5.2 mmol) in tert-BuNH2 (2.0 g. 27 mmol) was heated to reflux for 4 h, evaporated, diluted with Et2O, filtered, and concentrated to afford the title compound. 1H NMR (CDCl3) δ 2.67 (t, 2H), 2.27 (td, 2H), 1.96 (t, 1H), 1.70 (quint., 2H), 1.11 (s, 9H).

후처리

temperatureto reflux for 4 h
customevaporated
additiondiluted with Et2O
filtrationfiltered
concentrationconcentrated

출처 및 근거

ORD 기록: ord-278f103381b04ae7aaf078b768d5199a
출처 데이터셋: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08093229B2

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