1,4-Bis(dihydroquinidine)phthalazine → (R)-4-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)but-3-yne-1,2-diol

참여 물질

역할	이름	HCID	투입량
반응물	1,4-Bis(dihydroquinidine)phthalazine	HCID 11217202	—
반응물	t-Butanol tetrahydrofuran water	HCID 22124471	—
반응물	5-(but-3-en-1-ynyl)-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine	HCID 57713813	—
생성물	(R)-4-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)but-3-yne-1,2-diol	HCID 57713808	—

반응 단계

Treatment of 5-(but-3-en-1-ynyl)-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine (see example 46) (35 mg) with AD-mix-β (Aldrich, 540 mg) in t-BuOH:THF:water 1:1:1 (6 mL) at rt overnight, followed by work-up and reverse-phase preparative HPLC gave the title compound (10 mg), as a solid. HPLC Rt=4.13 min

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08093229B2
출처 데이터셋	uspto-grants-2012_01
ORD ID	ord-4e185b1b4b5245d894c17f88949288b9
출처 메모	uspto-grants-2012_01