Chloroacetyl chloride → 6-Phenyl-4H-benzo[1,4]oxazin-3-one

참여 물질

역할	이름	HCID	투입량
반응물	Chloroacetyl chloride	HCID 6577	—
반응물	Triethylamine	HCID 8471	—
반응물	2-Amino-4-phenylphenol	HCID 14562	—
반응물	Sodium hydride	HCID 24758	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	6-Phenyl-4H-benzo[1,4]oxazin-3-one	HCID 11579477	98.7%

반응 단계

Using 2-amino-4-phenylphenol (1 g, 5.4 mmol), triethylamine (0.97 mL, 7.0 mmol) and chloroacetyl chloride (0.72 g, 5.9 mmol) in THF (35 mL) followed by sodium hydride (0.27 g of a 60% suspension in oil, 6 mmol) to yield the title compound as a pale yellow solid (1.2 g, 91%). δH (DMSO-d6) 4.62 (2H, s), 7.29-7.56 (8H, m), 10.81 (1H, s).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08093238B2
출처 데이터셋	uspto-grants-2012_01
ORD ID	ord-545c08162c054aa1a818abe0a1fbf826
출처 메모	uspto-grants-2012_01