Aminomalononitrile p-toluenesulphonate → HCID 178430961, 화합물

HRID 418004

반응식

HRID 418004 반응식
C1(C)C=CC(S(O)(=O)=O)=CC=1.[NH2:12][CH:13]([C:16]#[N:17])[C:14]#[N:15].[CH:18](=[N:22][OH:23])[C:19]([CH3:21])=O>CC(O)C>[NH2:15][C:14]1[C:13]([C:16]#[N:17])=[N:12][C:19]([CH3:21])=[CH:18][N+:22]=1[O-:23]

참가 물질

4

반응물 2

HCID 563049Aminomalononitrile p-toluenesulphonateHCID 63992132-Oxopropanal-1-oxime

생성물 1

HCID 178430961HCID 178430961, 화합물수율 90.2%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Aminomalononitrile p-toluenesulfonate salt (20.0 g, 79 mmol) and pyruvaldehyde 1-oxime (6.88 g, 79 mmol) were combined in a flask. iPrOH (140 mL) was added, and the resulting yellow slurry was allowed to stir at room temperature for 18 h, during which time a yellow precipitate accumulated. The mixture was filtered and the precipitate was washed with iPrOH (2×50 mL) and DI H2O (20 mL), then lyophilized to give 2-amino-3-cyano-5-methypyrazine N-oxide (10.7 g).

후처리

  1. filtrationThe mixture was filtered
  2. washthe precipitate was washed with iPrOH (2×50 mL) and DI H2O (20 mL)

출처 및 근거

ORD 기록
ord-413b1cd18a144742a09ab32d88c2f064
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093244B2

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