Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → Formate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-Chloro-p-anisic acid | HCID 169982 | — |
| 반응물 | HCID 44819544 | HCID 44819544 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Formate | HCID 283 | 423.1% |
| 생성물 | HCID 25054307 | HCID 25054307 | — |
반응 단계
A reaction vial was charged with 3-chloro-4-methoxybenzoic acid (40 mg, 0.21 mmol), 3-aminomethyl-N-(4-dimethylaminomethyl-phenyl)-benzamide (40 mg, 0.14 mmol), EDC (40 mg, 0.25 mmol) and HOBt (40 mg, 0.29 mmol). DMF (2 mL) was added followed by Hunig's base (0.11 mL, 0.57 mmol). The mixture was stirred at room temperature for 16 h. The product was purified by preparative HPLC using an acetonitrile/water/formic acid gradient providing the title compound as a formate salt (20 mg, 31% yield); MS, electrospray, 452 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08093266B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-332f0387552244a0a63ba1c192ea222c |
| 출처 메모 | uspto-grants-2012_01 |