2,5-Dimethyl-1H-indole → 4-(2,5-Dimethyl-1H-indol-3-yl)-8-(trifluoromethyl)-quinoline, hydrochloride

참여 물질

역할	이름	HCID	투입량
반응물	2,5-Dimethyl-1H-indole	HCID 70965	—
반응물	4-Chloro-8-(trifluoromethyl)quinoline	HCID 90262	—
용매	Hydrochloric Acid	HCID 313	—
용매	N-methyl-2-pyrrolidone	HCID 13387	—
용매	1,4-Dioxane	HCID 31275	—
생성물	4-(2,5-Dimethyl-1H-indol-3-yl)-8-(trifluoromethyl)-quinoline, hydrochloride	HCID 131729345	67%

반응 조건

온도	140 °C

반응 단계

A mixture of 2,5-dimethylindole (765 mg) and 4-chloro-8-trifluoromethylquinoline (1.22 g) in NMP (1.5 ml) and 4M HCl in dioxane (0.2 ml) was heated at 140° C. for 1 h. After cooling the mixture was triturated with ether and filtered to give the sub-title compound (1.33 g) as a dark red solid.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08093278B2
출처 데이터셋	uspto-grants-2012_01
ORD ID	ord-3d83c96dcd864fa89b3975550fedd3df
출처 메모	uspto-grants-2012_01