Water → 2-(2,5-dimethyl-1H-indol-3-yl)-benzoxazole

HRID 418430노트

반응식

HRID 418430 반응식
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([CH3:11])=[CH:6][CH:5]=2.Cl[C:13]1[O:14][CH:15]=[CH:16][N:17]=1.CN1[C:23](=O)[CH2:22][CH2:21][CH2:20]1.O>CCOC(C)=O>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[C:13]1[O:14][C:15]3[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=3[N:17]=1)=[CH:8][C:7]([CH3:11])=[CH:6][CH:5]=2

참가 물질

6

반응물 4

HCID 962WaterHCID 13387N-methyl-2-pyrrolidoneHCID 709652,5-Dimethyl-1H-indoleHCID 133710742-Chloro-1,3-oxazole

생성물 1

HCID 684575182-(2,5-dimethyl-1H-indol-3-yl)-benzoxazole

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

2,5-dimethyl indole (0.3 g), 2-chlorooxazole (0.47 g) and NMP (2 ml) were heated in a microwave at 100 watts for 20 min at 160° C. Water ane EtOAc were added and separated, the aqueous phase was re-extracted with EtOAc (×4). The combined organic extracts were dried (MgSO4) and concentrated in vacuo. The precipitate was triturated with EtOAc then recrystallised from methanol to give the title compound (0.19 g).

후처리

  1. customseparated
  2. extractionthe aqueous phase was re-extracted with EtOAc (×4)
  3. dry with materialThe combined organic extracts were dried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customThe precipitate was triturated with EtOAc
  6. customthen recrystallised from methanol

출처 및 근거

ORD 기록
ord-1c7720cdc9f248b9ade995052acb0d4c
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093278B2

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