Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,7-Dichloroquinoline → 7-chloro-4-(5-fluoro-2-methyl-1H-indol-3-yl)-quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,7-Dichloroquinoline | HCID 6866 | — |
| 반응물 | 5-Fluoro-2-methylindole | HCID 2778715 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 7-chloro-4-(5-fluoro-2-methyl-1H-indol-3-yl)-quinoline | HCID 68458195 | 80.5% |
반응 단계
A solution of 5-fluoro-2-methylindole (149 mg) and 4,7-dichloroquinoline (198 mg) in NMP (2 ml) and 4M hydrogen chloride in dioxan (0.2 ml) was stirred at 140° C. overnight and then at 150° C. for 1 h. and evaporated. The residue was taken up in ethyl acetate, washed with brine (3×), dried (MgSO4) and evaporated in vacuo. The residue was purified by silica chromatography using acetone/isohexane (2:8) as eluent to give the sub-title compound (250 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08093278B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-fb62c8b020ba418e8f05ec14c5a0d741 |
| 출처 메모 | uspto-grants-2012_01 |