Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → 5-Chloro-2-methyl-3-(8-quinolinyl)-1H-indole-1-acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Lithium Chloride | HCID 433294 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Quinoline-7-boronic acid | HCID 21886457 | — |
| 촉매 | Tetrakis palladium triphenylphosphine | HCID 86600928 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-Chloro-2-methyl-3-(8-quinolinyl)-1H-indole-1-acetic acid | HCID 10383271 | — |
반응 단계
The product of part b (250 mg), 7-quinoline boronic acid (114 mg), 2M sodium bicarbonate (0.7 ml), toluene, ethanol, tetrakis palladium triphenyl phosphine (O) and lithium chloride were heated at reflux for 2 hours. The reaction mixture was concentrated in vacuo, purified using amine resin and then by reverse phase preparative HPLC to give the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08093278B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-fd2c68541ba04a9aa2532959621190bc |
| 출처 메모 | uspto-grants-2012_01 |