Methanol → (R)-2-(6-Chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

HRID 418488노트

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HRID 418488 반응식
[Cl:1][C:2]1[C:3]([N+:13]([O-:15])=[O:14])=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])O[CH:6]=[CH:5]2.CO.C(N(CC)CC)C.Cl.[NH2:26][C@H:27]([CH3:31])[C:28]([NH2:30])=[O:29]>>[Cl:1][C:2]1[C:3]([N+:13]([O-:15])=[O:14])=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:26]([C@H:27]([CH3:31])[C:28]([NH2:30])=[O:29])[CH:6]=[CH:5]2

참가 물질

5

반응물 4

HCID 887MethanolHCID 8471TriethylamineHCID 2775814(2R)-2-Aminopropanamide hydrochlorideHCID 595157256-Chloro-5-nitro-1H-isochromen-1-one

생성물 1

HCID 59515858(R)-2-(6-Chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

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온도
55 °C

실험 절차

To a solution of 6-chloro-5-nitro-1H-isochromen-1-one (950 mg, 0.0042 mol) in methanol (30 mL, 0.7 mol) was added triethylamine (0.64 mL, 0.0046 mol) and (R)-2-aminopropanamide hydrochloride (0.58 g, 0.0046 mol). The reaction was heated to 55° C. overnight and the solvent was removed under reduced pressure. The residue was purified by flash chromatography to afford the product as light yellow solid.

후처리

  1. customthe solvent was removed under reduced pressure
  2. customThe residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-ad4264adc4504056827fada3c9089b58
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093265B2

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