Ethanol → (R)-2-(5-Amino-6-cyclopropyl-1-oxoisoquinolin-2(1H)-yl)propyl acetate

HRID 418504노트

반응식

HRID 418504 반응식
[C:1]([O:4][CH2:5][C@H:6]([N:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH:21]3[CH2:23][CH2:22]3)[C:14]=2[N+:18]([O-])=O)[C:9]1=[O:24])[CH3:7])(=[O:3])[CH3:2].C(O)C>[Pd]>[C:1]([O:4][CH2:5][C@H:6]([N:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH:21]3[CH2:22][CH2:23]3)[C:14]=2[NH2:18])[C:9]1=[O:24])[CH3:7])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 702EthanolHCID 59515735(R)-2-(6-Cyclopropyl-5-nitro-1-oxoisoquinolin-2(1H)-yl)propyl acetate

생성물 1

HCID 59515874(R)-2-(5-Amino-6-cyclopropyl-1-oxoisoquinolin-2(1H)-yl)propyl acetate

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

A round bottom flask was charged with (R)-2-(6-cyclopropyl-5-nitro-1-oxoisoquinolin-2(1H)-yl)propyl acetate (28 mg, 0.000085 mol), ethanol (10 mL, 0.2 mol) and palladium, 10% weight on charcoal (1.0 mg, 0.0000085 mol) was added. The flask was evacuated and flushed with hydrogen two times and the reaction was stirred under hydrogen (1 atm) for 2 hours. The reaction was filtered over celite and the solvent was removed to afford the product.

후처리

  1. additionwas added
  2. customThe flask was evacuated
  3. customflushed with hydrogen two times
  4. filtrationThe reaction was filtered over celite
  5. customthe solvent was removed
  6. customto afford the product

출처 및 근거

ORD 기록
ord-92b0d683d2f5487ebe3ee666333173f7
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093265B2

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