Methanol → (R)-N-(6-Cyclopropyl-2-(1-hydroxypropan-2-yl)-1-oxo-1,2-dihydroisoquinolin-5-yl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

HRID 418506노트

반응식

HRID 418506 반응식
C([O:4][CH2:5][C@H:6]([N:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH:33]3[CH2:35][CH2:34]3)[C:14]=2[NH:18][C:19](=[O:32])[CH2:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[C:23]([F:31])[CH:22]=2)[C:9]1=[O:36])[CH3:7])(=O)C.C(=O)([O-])[O-].[K+].[K+].CO>O>[CH:33]1([C:13]2[C:14]([NH:18][C:19](=[O:32])[CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:28])([F:30])[F:29])=[C:23]([F:31])[CH:22]=3)=[C:15]3[C:10](=[CH:11][CH:12]=2)[C:9](=[O:36])[N:8]([C@H:6]([CH3:7])[CH2:5][OH:4])[CH:17]=[CH:16]3)[CH2:35][CH2:34]1

참가 물질

5

반응물 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 59515703(R)-2-(6-Cyclopropyl-5-(2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamido)-1-oxoisoquinolin-2(1H)-yl)propyl acetate

생성물 1

HCID 25013921(R)-N-(6-Cyclopropyl-2-(1-hydroxypropan-2-yl)-1-oxo-1,2-dihydroisoquinolin-5-yl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

시약·촉매·용매 1

HCID 962Water촉매

실험 절차

A round bottom flask was charged with (R)-2-(6-cyclopropyl-5-(2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamido)-1-oxoisoquinolin-2(1H)-yl)propyl acetate (23 mg, 0.000046 mol), potassium carbonate (9.4 mg, 0.000068 mol) and methanol (2 mL, 0.05 mol) and 2 drops of water and the reaction was stirred for 30 minutes. The reaction mixture was filtered over celite and the solvent removed under reduced pressure. The residue was purified by reverse phase preparative HPLC to afford the product.

후처리

  1. filtrationThe reaction mixture was filtered over celite
  2. customthe solvent removed under reduced pressure
  3. customThe residue was purified by reverse phase preparative HPLC
  4. customto afford the product

출처 및 근거

ORD 기록
ord-28e8ca494e46447baf7519daf273194c
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093265B2

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