Ethanol → HCID 59515926, 화합물

HRID 418507노트

반응식

HRID 418507 반응식
[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8]1[C:9]([N+:25]([O-])=O)=[C:10]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])[N:13]([CH2:19][CH2:20][O:21][C:22](=[O:24])[CH3:23])[CH:12]=[CH:11]2)(=[O:3])[CH3:2].C(O)C.[Cl-].[NH4+].O>[Fe]>[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8]1[C:9]([NH2:25])=[C:10]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])[N:13]([CH2:19][CH2:20][O:21][C:22](=[O:24])[CH3:23])[CH:12]=[CH:11]2)(=[O:3])[CH3:2]

참가 물질

6

반응물 4

HCID 702EthanolHCID 962WaterHCID 25517Ammonium ChlorideHCID 595159322-(2-(2-Acetoxyethyl)-5-nitro-1-oxo-1,2-dihydroisoquinolin-6-ylamino)ethyl acetate

생성물 1

HCID 59515926HCID 59515926, 화합물

시약·촉매·용매 1

HCID 23925Iron촉매

실험 절차

A mixture of 2-(2-(2-acetoxyethyl)-5-nitro-1-oxo-1,2-dihydroisoquinolin-6-ylamino)ethyl acetate (350 mg, 0.00093 mol), ethanol (20 mL, 0.3 mol), ammonium chloride (496.1 mg, 0.009275 mol) and water (10 mL, 0.6 mol) was added at 85° C. Iron (207 mg, 0.00371 mol) was added in two portions, five minutes apart, and was stirred at that temperature for 1 hour. The reaction mixture was then poured onto methylene chloride (100 mL) and the layers were separated. The organic layer was washed with brine and dried. the solvent was removed under reduced pressureunder reduced pressure and the product was used in the next step without purification.

후처리

  1. additionwas added at 85° C
  2. additionThe reaction mixture was then poured onto methylene chloride (100 mL)
  3. customthe layers were separated
  4. washThe organic layer was washed with brine
  5. customdried
  6. customthe solvent was removed
  7. customthe product was used in the next step without purification

출처 및 근거

ORD 기록
ord-30174058609845b4892506d10d30d5ff
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093265B2

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