Methanol → 2-(2-Fluoro-3-(trifluoromethyl)phenyl)-N-(2-(2-hydroxyethyl)-6-(2-hydroxyethylamino)-1-oxo-1,2-dihydroisoquinolin-5-yl)acetamide

HRID 418509노트

반응식

HRID 418509 반응식
C([O:4][CH2:5][CH2:6][NH:7][C:8]1[C:9]([NH:25][C:26](=[O:39])[CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[C:29]=2[F:38])=[C:10]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])[N:13]([CH2:19][CH2:20][O:21]C(=O)C)[CH:12]=[CH:11]2)(=O)C.C(=O)([O-])[O-].[K+].[K+].CO>O>[F:38][C:29]1[C:30]([C:34]([F:37])([F:36])[F:35])=[CH:31][CH:32]=[CH:33][C:28]=1[CH2:27][C:26]([NH:25][C:9]1[C:8]([NH:7][CH2:6][CH2:5][OH:4])=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[CH:12][N:13]([CH2:19][CH2:20][OH:21])[C:14]2=[O:18])=[O:39]

참가 물질

5

반응물 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 59515734HCID 59515734, 화합물

생성물 1

HCID 247608872-(2-Fluoro-3-(trifluoromethyl)phenyl)-N-(2-(2-hydroxyethyl)-6-(2-hydroxyethylamino)-1-oxo-1,2-dihydroisoquinolin-5-yl)acetamide

시약·촉매·용매 1

HCID 962Water촉매

실험 절차

A round bottom flask was charged with 2-(2-(2-acetoxyethyl)-5-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetamido)-1-oxo-1,2-dihydroisoquinolin-6-ylamino)ethyl acetate (120 mg, 0.00022 mol), potassium carbonate (45 mg, 0.00033 mol) and methanol (3 mL, 0.07 mol) and 2 drops of water. The reaction was stirred at room temperature for 30 minutes, filtered over sodium sulfate, and the solvent removed under reduced pressure. The residue was purified by flash chromatography to afford the product as a white solid.

후처리

  1. filtrationfiltered over sodium sulfate
  2. customthe solvent removed under reduced pressure
  3. customThe residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-2aedd5525a3944b3ab456227f4a05157
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093265B2

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